C-2/C-3 Annulation and C-2 Alkylation of Indoles with 2-Alkoxycyclopropanoate Esters
نویسندگان
چکیده
منابع مشابه
C-2/c-3 annulation and C-2 alkylation of indoles with 2-alkoxycyclopropanoate esters.
The annulation reaction between various indoles and 2-alkoxycyclopropanoate esters is reported. Both high efficiency and complete stereochemical control were observed in some cases with this annulation process. A single stereocenter on the cyclopropane controls the diastereoselective formation of up to four new stereocenters. A different reaction course was observed with 3-substituted indole su...
متن کاملCu-mediated direct regioselective C-2 chlorination of indoles.
Cu-mediated C-2 chlorination of indoles was accomplished with copper(ii) chloride through the use of a directing pyrimidyl protection group. A highly regioselective manner can be achieved on a range of indole substrates with excellent functional group tolerance.
متن کاملC 3 . 2 Mutation
See the individual abstracts for sections C3.2.1–C3.2.6. C3.2.1 Binary strings
متن کاملEnantioselective dearomative [3 + 2] cycloadditions of indoles with azomethine ylides derived from alanine imino esters†
Catalytic, enantioselective [3 + 2] cycloadditions of azomethine ylides derived from alanine imino esters with 3-nitroindoles are reported. The dearomative cycloaddition reactions occur in the presence of a catalyst generated in situ from Cu(OTf)2 and (R)-Difluorphos to form exo’-pyrroloindoline cycloadducts and establish four contiguous stereogenic centers, two of which are fully substituted. ...
متن کاملRuthenium/TFA-catalyzed regioselective C-3-alkylation of indoles with terminal alkynes in water: efficient and unprecedented access to 3-(1-methylalkyl)-1H-indoles.
An unprecedented C-3-alkylation reaction of indoles with terminal alkynes in aqueous medium has been developed using catalytic amounts of ruthenium and trifluoroacetic acid.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2007
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja067821+